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Diagnostic exome sequencing in persons with severe intellectual disability

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Persistent iron deficiency may provide an early clue, even when anemia or other symptoms are absent

In previous phylogenetic analyses conducted with other gene families of the thioredoxin superfamily, e.g., thioredoxins, glutaredoxins, peroxiredoxins and PDIs, the gene structure (number of exons in eukaryotic genes) was conserved and coherent with the classes (Meyer et al., 2002

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